Molecular Mechanisms Mediating Contraction-Induced Metabolic Gene Expression and Function in Skeletal Muscle

Histone modifications and skeletal muscle metabolic gene expression

SL McGee, M Hargreaves

2010-03-01

Skeletal muscle oxidative function and metabolic gene expression are co-ordinately downregulated in metabolic diseases such as ins..

Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

JH Ryu, J Drain, JH Kim, S McGee, A Gray-Weale, L Waddington, GJ Parker, M Hargreaves, SH Yoo, D Stapleton

2009-12-01

Glycogen is a cellular energy store that is crucial for whole body energy metabolism, metabolic regulation and exercise performanc..

Exercise-induced histone modifications in human skeletal muscle

SL McGee, E Fairlie, AP Garnham, M Hargreaves

2009-12-01

Skeletal muscle adaptations to exercise confer many of the health benefits of physical activity and occur partly through alteratio..

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle

MJ Gibala, SL McGee, AP Garnham, KF Howlett, RJ Snow, M Hargreaves

2009-03-01

From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linke..

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

H Boon, M Bosselaar, SFE Praet, EE Blaak, WHM Saris, AJM Wagenmakers, SL McGee, CJ Tack, P Smits, M Hargreaves, LJC Van Loon

2008-10-01

Aims/hypothesis: The 5′-AMP-activated protein kinase (AMPK) pathway is intact in type 2 diabetic patients and is seen as a target ..

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

SL McGee, BJW Van Denderen, KF Howlett, J Mollica, JD Schertzer, BE Kemp, M Hargreaves

2008-04-01

OBJECTIVE-Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal m..